News Summary
The Coble family, who endured the heartbreaking loss of their three children in a tragic accident sixteen years ago, is facing new adversity. Lori Coble has been diagnosed with Stage IV Glioblastoma, a severe form of brain cancer. Emergency surgery removed a significant portion of the tumor, but the remaining mass is inoperable. As the family begins intensive treatment, a GoFundMe page has been set up to help with medical expenses, illustrating the ongoing community support for a family that has inspired many through their resilience.
Mission Viejo, California – The Coble family is facing another tragedy as Lori Coble, the mother who lost her three children in a devastating crash 16 years ago, has been diagnosed with Stage IV Glioblastoma, a type of brain cancer that is known to be both aggressive and incurable. The diagnosis came after Lori experienced concerning symptoms that led her to seek emergency medical attention.
Doctors have performed emergency surgery on Lori, successfully removing 80% of the tumor; however, the remaining portion is deemed inoperable due to its location behind her right eye. Following the surgery, Lori has begun an intensive treatment regimen that includes chemotherapy and radiation, which is expected to be both physically and emotionally taxing for the entire family.
The family described their current situation as a “steep and uncertain” road ahead, emphasizing that the burden of their experiences is “simply too much for one family to carry alone.” In light of these recent developments, a GoFundMe page has been established to provide financial assistance to the Coble family as they navigate through this challenging period.
The Coble family’s resilience has been put to the test since 2007 when Lori and her husband, Chris Coble, experienced unimaginable loss. In that tragic year, the couple lost their three young children—Kyle, Emma, and Katie—during a crash on Interstate 5 in Mission Viejo, California, when a big rig collided with their minivan. The incident drew international attention and sparked discussions about highway safety, leading to advocacy for stronger trucking regulations.
Following the loss of their children, the Cobles welcomed triplets—Ellie, Ashley, and Jake—who are now high school seniors. Their story of recovery and hope has inspired many people worldwide, showcasing the profound strength of the human spirit in the face of tragedy.
The 2007 crash not only shattered the lives of those directly involved but also raised awareness about the dangers of highway travel. The incident prompted former Senator Dianne Feinstein to call for regulatory reforms in the trucking industry, underscoring the importance of implementing common-sense measures that could enhance highway safety and prevent similar tragedies.
Despite the challenges, the Coble family has worked to honor the memory of their lost children while simultaneously building a new life with their surviving triplets. However, the recent diagnosis of Lori has brought a new wave of uncertainty and fear, as the family grapples with the potential implications of her illness.
The GoFundMe initiative aims to provide relief amidst medical expenses and other related costs, allowing the family to focus on treating Lori and cherishing the moments they have together. The community, which has followed the Cobles’ journey over the years, is now rallying around them once again in this time of need, illustrating the strong support system that has developed since their initial loss.
As the Coble family navigates through this difficult chapter, they remain a powerful example of resilience and hope, reminding all those who hear their story of the unpredictable nature of life and the vital importance of community support during the hardest of times.
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Additional Resources
- Orange County Register: Woman killed in head-on car crash
- Wikipedia: Highway safety
- Patch: DUI suspected in fatal wrong-way Mission Viejo crash
- Google Search: Traffic safety
- ABC7 News: Will Ferrell among 4 injured in rollover crash
- Google Scholar: Traffic accidents
- KTLA: Firefighters injured in rollover crash
- Encyclopedia Britannica: Car crashes
- US Accident Lawyer: Heavy traffic multi-car accident
- Google News: Motor vehicle crashes

Author: STAFF HERE MISSION VIEJO WRITER
MISSION VIEJO STAFF WRITER The MISSION VIEJO STAFF WRITER represents the experienced team at HEREMissionViejo.com, your go-to source for actionable local news and information in Mission Viejo, Orange County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as Oso Fit 5K Fun Run and Community Health Fair, Walk Against Drugs & Community Fair, and National Night Out. Our coverage extends to key organizations like the Mission Viejo Chamber of Commerce and Providence Mission Hospital Mission Viejo, plus leading businesses in retail and education that power the local economy such as The Shops at Mission Viejo, Capistrano Unified School District, and Amazon Delivery Station. As part of the broader HERE network, including HEREAnaheim.com, HEREBeverlyHills.com, HERECostaMesa.com, HERECoronado.com, HEREHollywood.com, HEREHuntingtonBeach.com, HERELongBeach.com, HERELosAngeles.com, HERESanDiego.com, and HERESantaAna.com, we provide comprehensive, credible insights into California's dynamic landscape.